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Foveal microvasculature, refractive errors, optical biometry and their correlations in school-aged children with retinopathy of prematurity after intravitreal antivascular endothelial growth factors or laser photocoagulation

British Journal of Ophthalmology Aug 24, 2019

Chen YC, et al. - In children with a history of type 1 retinopathy of prematurity (ROP) treated with either laser photocoagulation or intravitreal injection of antivascular endothelial growth factors (anti-VEGF), researchers conducted this retrospective and comparative case series to compare the differences and to evaluate the associations regarding to foveal microvasculature, refractive errors and optical biometry. In total, 47 eyes in 25 children were analyzed. Investigators found that laser-treated eyes had significantly smaller fovea avascular zone, higher fovea vessel density (VD), lower parafoveal VD, thicker inner retinal thickness. Laser-treated eyes had a much greater myopia degree. Despite similar visual acuity results, those who underwent anti-VEGF injection had favourable developmental results vs laser photocoagulation in school-age children with type 1 ROP history. There are significant correlations between fovea microvasculature and optical biometric components.
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