Brich S, Bozzi F, Perrone F, et al. - Fluorescence in situ hybridization (FISH) was conducted on 75 formalin-fixed-paraffin-embedded peritoneal mesotheliomas and two types of monoallelic loss (monosomy, and hemizygous deletion) and two types of biallelic loss (canonical homozygous deletion with a complete loss of FISH signal and homozygous deletion with diminished signal) were identified in order to evaluate the performance of FISH in recognizing the copy number profiles of the three key peritoneal mesothelioma tumor suppressor genes BAP1, CDKN2A, and NF2, with special importance on minute homozygous deletions, a copy number abnormality newly revealed at the 3p21 (BAP1) chromosomal region using high-throughput methods. Array comparative genomic hybridization done on a spontaneously emerging peritoneal mesothelioma cell line gave support for the account of the FISH patterns and permitted to lengthen the number of chromatin remodeling factors included in mesothelioma to SETD7 and PCGF5 which are two formerly unreported genes.