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Five-year health status after self-expanding transcatheter or surgical aortic valve replacement in high-risk patients with severe aortic stenosis

JAMA Cardiology Jan 14, 2021

Arnold SV, Chinnakondepalli KM, Magnuson EA, et al. - The long-term health status outcomes after transcatheter vs surgical aortic valve placement in high-risk patients were determined. Researchers conducted a randomized clinical trial including 713 patients at high surgical risk with severe aortic stenosis who completed a baseline Kansas City Cardiomyopathy Questionnaire (KCCQ) and randomized them to either self-expanding TAVR or SAVR. Findings revealed a high long-term mortality in these high-risk patients. However, large improvements occurred in the majority of surviving patients treated with either transcatheter or surgical aortic valve replacement; the improvements remained stable through 2 years with gradual decline thereafter. Although the 2 treatments showed marked differences in the complication profiles, there were no differences in health status between treatment groups from 6 months through 5 years.

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