Clifford C, Sethi M, Cox D, et al. - In view of an all-time high rates of emergency department (ED) visits for acute drug overdose, researchers here investigated how treatment with vasopressors, both push-dose and infusion, for circulatory shock in this patient population affect the mortality outcome. They analyzed 55 patients with circulatory shock, which is defined as hypotension necessitating either vasopressors, high-dose insulin euglycemia therapy, or both. Among these cases, there was 20% 24-hour mortality, 42% in-hospital mortality, 730-minute mean vasopressor duration, and 53.4-hour median ICU LOS. Findings revealed the first-line vasopressor to be correlated with in-hospital mortality among ED patients with undifferentiated drug overdose and circulatory shock. The lowest odds of in-hospital mortality were observed in correlation with first-line push-dose phenylephrine.