Campbell DJT, Campbell DB, Ogundeji Y, et al. - Researchers herein analyzed real-world prescription data from Alberta, Canada with the aim to delineate the prescribing patterns for initial pharmacotherapy for those with newly-diagnosed uncomplicated type 2 diabetes. In addition, they sought to report medication-taking behaviors (adherence and persistence) in the first year after starting pharmacotherapy and estimated healthcare system costs linked with prescribing patterns. A cohort of those with uncomplicated incident diabetes was defined utilizing a retrospective cohort design using linked administrative datasets from 2012-2017. A prescription for metformin monotherapy (89%) was made for the majority of individuals for whom metformin was indicated as first-line therapy. The addition of new classes of medications has provided more pharmaceutical options than ever to the healthcare providers who look after those with type 2 diabetes. Most individuals continue to receive metformin monotherapy prescription. However, there were suboptimal adherence and considerable drops off within the first 3 months.