Hissong E, et al. - Researchers assessed if the features of luminal debris, including microorganisms, from ulcerated gastric cancers were significantly different from those of debris correlated with benign ulcers. Fifty ulcerated adenocarcinomas and 50 site-matched peptic ulcers were retrospectively identified. They assessed luminal debris for the nature of inflammation, necrosis, and the presence of mixed bacterial colonies or yeasts. In addition, the non-lesional mucosa was evaluated for chronic gastritis, Helicobacter pylori, chemical gastropathy, and intestinal metaplasia. Gastric cancers might be colonized by non-H. pylori microorganisms. Findings revealed that identification of numerous bacterial colonies, filamentous bacteria, or fungi in biopsy material obtained from ulcerated gastric lesions should increase suspicion for underlying malignancy.