McDonald J, et al. - A cross-sectional study was conducted to ascertain the feasibility of major salivary gland ultrasound (SGUS) in a clinic setting and to identify characteristics in a cohort of childhood-onset systemic lupus erythematosus (cSLE) patients (without confirmed SS) that may be associated with salivary gland abnormalities consistent with secondary Sjögren’s syndrome (SS). Researchers recruited a total of 31 cSLE patients, 84% were female, 55% were Caucasian. Furthermore, t-tests and Fisher’s exact tests were used to compare disease and demographic differences between cSLE patients with abnormal SGUS vs. cSLE patients with normal SGUS. This is the first research that evaluates major SGUS in a cohort of patients with cSLE without a prior diagnosis of SS. The data demonstrate that SGUS protocol was useful to conduct by rheumatologists in a clinic setting. SGUS abnormalities were distinguished in one-third of patients, although the sample size was small. The outcomes suggested that IgG level at diagnosis and anti-Ro and anti-La antibodies may be correlated with SGUS abnormalities.