Xu H, Hashem A, Witasp A, et al. - By performing this cross-sectional analysis, researchers examined the links of fibroblast growth factor 23 (FGF23) with renal sodium handling and blood pressure among non-dialysis CKD patients (n = 180). Baseline measurements of plasma intact FGF23, 24-h urinary sodium excretion, fractional excretion of sodium (FENa) and blood pressure were obtained. Using multivariate regression analysis, the link between FGF23 and renal sodium handling was investigated. The study sample had a median age of 52.8 years and comprised 60.6% men. The median estimated glomerular filtration rate was 50.6 mL/min/1.73 m². Findings revealed an independent link of FGF23 with raised FENa in non-dialysis CKD patients. The idea that FGF23 results in clinically significant sodium retention was not supported by the findings.