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Fetal neurosonography detects differences in cortical development and corpus callosum in late‐onset small fetuses

Ultrasound in Obstetrics & Gynecology Jan 16, 2021

Paules C, Miranda J, Policiano C, et al. - In late‐onset small fetuses sub‐classified into small-for‐gestational-age (SGA) or fetal growth restriction (FGR), this study was attempted to assess if neurosonography can detect variations in cortical development and corpus callosum length. Researchers conducted a prospective cohort study including a total of 318 singleton pregnancies, with 97 normally grown and 221 late‐onset small fetuses (birth weight below the 10 th centile diagnosed after 32 weeks of gestation). The outcomes of this study exhibited that, in late‐onset small fetuses, neurosonography appears to be able to diagnose subtle structural variations in brain development. Both SGA and FGR showed significantly thicker insula depth vs controls. A linear tendency to decreased Sylvian fissure depth (mm) was also seen across study groups. Corpus callosum length was significantly decreased in FGR cases; no differences were seen between SGA and controls. In parieto‐occipital sulcus depth, no differences were seen.

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