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Fertility of women treated during childhood with triptorelin (depot formulation) for central precocious puberty: The PREFER study

Hormone Research in Paediatrics Apr 01, 2021

Martinerie L, de Mouzon J, Blumberg J, et al. - For children with central precocious puberty (CPP), the standard of care includes gonadotropin-releasing hormone analogues (GnRHa) administered as depot formulations. Researchers herein examined fertility among women who underwent treatment with GnRHa for CPP during childhood. They performed the PREFER (PREcocious puberty, FERtility) study via prospectively analyzing fertility, through a series of questionnaires, in women treated during childhood with triptorelin (depot formulation) for CPP. Of a total of 574 identified women, 194 women were included in the analysis. Among analyzed women, there were only a few women (1.7%) who reported issues with fertility or were unable to become pregnant despite trying to conceive. Outcomes overall suggest no negative impact of CPP treated with triptorelin on women’s fertility in adulthood.

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