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Female obesity increases the risk of miscarriage of euploid embryos

Fertility and Sterility Dec 06, 2020

Mauro C, García-Velasco JA, Marcos M, et al. - This retrospective, observational, multicenter cohort study was undertaken to determine if female body mass index (BMI) is correlated with an increased risk of miscarriage after euploid embryo transfer. Three thousand four hundred eighty cycles of in vitro fertilization with preimplantation genetic testing for aneuploidy in the blastocyst stage and euploid embryo transfer were divided into four groups according to patient BMI. According to BMI (kg/m2), cycles were divided into four groups: underweight (< 18.5; n = 155), normal weight (18.5–24.9; n = 2,549), overweight (25–29.9; n = 591), and obese (≥ 30; n = 185). Women with obesity experience a higher risk of miscarriage than women with a normal weight after euploid embryo transfer, implying that this result is responsible for other mechanisms other than aneuploidy.

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