Kourosh A, et al. - Given intestinal microbes have been shown to influence predisposition to atopic disease, including food allergy, researchers characterized fecal microbiomes to identify taxa that may impact the expression of food allergy. This study included children with IgE-mediated food allergies, siblings without food allergy, and non-allergic controls. These groups were compared using ANOVA and Welch's t test. They identified key differences in microbiome signatures between these groups. Relative to siblings and controls, enrichment for specific microbes within the Clostridia class and Firmicutes phylum (Oscillobacter valericigenes, Lachnoclostridium bolteae, Faecalibacterium sp.) was detected in food-allergic subjects. Overall, in the manifestation of food-allergic disease, the role of both genetic and environmental contributors was highlighted.