Goldwater D, Ventigan N, Shih L, et al. - As patients with advanced heart failure referred for transplant evaluation are commonly frail, researchers examined the feasibility of performing routine frailty assessments on transplant candidates as part of a comprehensive evaluation. The following two well-validated assessments were included in the frailty evaluation: Fried's Frailty Phenotype (FFP) and the Short Physical Performance Battery (SPPB), performed during inpatient hospitalization. Categorization of patients was done as frail, prefrail, or non-frail based on each assessment. Frailty assessment of 29 patients (mean age: 62.5 years; 21% women) with advanced heart failure was done over 14 months. Significantly less frailty was reported among patients who underwent transplant vs those who were not transplanted (FFP: 2.2 vs 3.5; SPPB: 9.8 vs 5.2). Significantly more frailty was reported among patients who died than those who remained alive (n = 7 vs 21; FFP: 2.6 vs 4.4; SPPB: 3.9 vs 7.7). The findings support the possibility for successful incorporation of frailty assessments into a comprehensive evaluation for heart transplant candidacy. Although transplantation is not contraindicated in the presence of frailty, there was less likelihood for transplantation and more likelihood to die among frail patients undergoing heart transplant evaluation. Frailty evaluation may allow recognition of cases who may benefit from additional support services to optimize quality of life and define goals of care.