Rajamäki A, Sunela K, Kuitunen H, et al. - In the clinical course of indolent lymphomas, a well-described event is histologic transformation (HT) to an aggressive lymphoma. Presence of both low grade and high grade lymphoma, during occurrence of HT, is commonly seen in different areas of the body. Researchers herein examined the benefit of a diagnostic FDG-PET/CT-guided rebiopsy from the maximum standardized uptake value (SUVmax) site in indolent lymphomas, to detect HT not identified in the first biopsy. They assessed a total of 85 patients with indolent lymphoma (follicular lymphoma, marginal zone B-cell lymphoma, or nodular lymphocyte-predominant Hodgkin's lymphoma) who had undergone a diagnostic FDG-PET/CT. During a median follow-up period of 41 months (range: 1–407 months), 8 of 85 (9.4%) patients experienced a biopsy-confirmed HT which was identified with a diagnostic FDG-PET/CT. Findings overall support the value of performing a rebiopsy based on a high SUVmax in a diagnostic FDG-PET/CT for identification of HT after the diagnosis or relapse of an indolent lymphoma.