Jeong SM, et al. - In this cross-sectional study involving 2,460 patients, researchers explored the link between the presence and severity of non-alcoholic fatty liver disease (NAFLD) and the volume of white matter hyperintensity (WMH). Participants in the study were those who voluntarily had health screening check-ups including brain magnetic resonance imaging and liver ultrasonography at the Health Promotion Center at Seoul National University Hospital from 2009 to 2013. Data revealed that NAFLD prevalence was 36.5% and the median volume of WMH in all participants was 1.1 ml. A favorable association with WMH volume was shown by NAFLD and its severity. A smaller volume of WMH was linked to presence of NAFLD. Moderate to severe NAFLD correlated to a smaller volume of WMH vs non-NAFLD. The negative relationship between NAFLD severity and WMH volume was only persistent in those with low FIB-4 index and low NAFLD fibrosis scores; those with high FIB-4 index and NAFLD fibrosis scores were positively associated.