Florea A, et al. - By including 37 children followed in the National Referral Centre of rare inflammatory brain and spinal diseases, researchers assessed fatigue, depression, and quality of life (QoL) in children with multiple sclerosis vs other acute demyelinating syndromes (ADS). For evaluation, they used the Expanded Disability Status Scale, the fatigue severity scale, the Multiscore Depression Inventory for Children, and the Pediatric Quality of Life Inventory. Compared to the ADS group, severe fatigue was reported less often in multiple sclerosis group (though it wasn’t significant), while depression was reported more often in the multiple sclerosis group compared to the ADS group. Both parents and children reported poor emotional and school functioning with regard to QoL in patients with multiple sclerosis. This investigation emphasized the importance of fatigue and depression in ADS children and especially in pediatric onset multiple sclerosis. In addition, the main concerns for parents and children in the multiple sclerosis group were difficulties in school and emotional functioning that need to be taken into account during their proposal for care and treatment.