Tokgoz Y, et al. - Authors ascertained if fat-soluble vitamin levels required routine analysis in children with celiac disease during diagnosis. They assessed the diagnosis symptoms of celiac patients (CD) in a newly diagnosed pediatric group along with fat-soluble vitamin levels simultaneous with intestinal biopsies between May 2015–May 2016. Growth retardation was discovered to be the most frequent symptom. A prominent lowness was established in vitamin D and A in newly diagnosed children with CD. The analysis of vitamin A and D levels would be beneficial in the course of diagnosis in these patients.

Methods

• Experts questioned the diagnosis symptoms of celiac patients (CD) in newly diagnosed pediatric group between May 2015-May 2016.
• An assessment was conducted of the fat soluble vitamin levels simultaneous with intestinal biopsies.
• During this study, vitamin levels were compared with those of healthy control group.

Results

• A scrutiny was carried out of 52 patients involving 27 female (51.9%), 25 male (48.1%); along with a total of 50 healthy control group including 25 female (50%), 25 male (50%).
• It was noted that the average age of patients was 9 ± 4.3 years, with an average weight of 16.2 ± 6.3 kg.
• Growth retardation appeared to be the most frequent symptom in the study cohort (61.5%).
• The other most commonly seen symptoms were abdominal pain (51.9%) and diarrhea (11.5%).
• Histological analysis revealed that Marsh 3B n = 23 (45.1%) was mostly established.
• Vitamin A and vitamin D levels of patients were notably lower compared to those of control group.
• Compared to the healthy control group, vitamin A and vitamin D deficiencies were considerably higher.
• It was observed that vitamin D insufficiency was seen in 48 patients (92.3%) and vitamin D deficiency was determined in 32 (61.5%) out of 48 and vitamin A deficiency was noted in 17 (32.7%) patients.
• No patients presented with vitamin E and vitamin K1 deficiency. In the healthy control group, vitamin D deficiency was seen in 2 (4%) patients, vitamin D insufficiency was determined in 9 (18%) patients.
• Healthy group exhibited normal levels for other vitamin levels.