Han X, et al. - Researchers examined if fasting C-peptide is a risk factor for nonalcoholic fatty liver disease (NAFLD). They assessed 520 obese children (376 male, 144 female) aged 3.4–17.1 years and divided them into two groups obese with NAFLD and non-NAFLD, according to hepatic ultrasound results. The obese children with NAFLD showed higher fasting C-peptide, fasting insulin and HOMA-IR when compared with the non-NAFLD group. Stepwise multiple logistic regression models suggested that for the presence of NAFLD in obese children, independent indicators are fasting C-peptide, white blood cell, albumin, alanine aminotransferase, triglycerides, and waist circumference. Moreover, following adjustment for confounding variables, significantly higher prevalence of NAFLD was observed in obese children according to increased serum fasting C-peptide levels. Findings thereby indicate an increased risk for developing NAFLD among obese children with a high level of fasting C-peptide.