Dario AB, Kamper SJ, O'Keeffe M, et al. - Via conducting a meta-analysis, researchers sought to quantify the effect of family history of pain on childhood musculoskeletal (MSK) pain. In addition, they examined if specific family pain factors determine the strength of the association (PROSPERO CRD42018090130). They included 6 longitudinal and 23 cross-sectional studies reporting on the aforementioned topic. Moderate quality evidence from 5 longitudinal studies (n = 42,131) showed that children with a family history of MSK pain had 58% increased odds of experiencing MSK pain themselves (odds ratio [OR] 1.58, 95% confidence interval 1.20-2.09). Moderate quality evidence from 18 cross-sectional studies (n = 17,274) supported this finding (OR 2.02, 95% 1.69-2.42). Subgroup analyses showed that the relationship was robust regardless of whether a child's mother, father, or sibling experienced pain. Odds were higher when both parents reported pain compared with one ([mother OR = 1.61; father OR = 1.59]; both parents OR = 2.0). These works yielded moderate-quality evidence indicating a higher risk of experiencing MSK pain among children with a family history of pain. As per subgroup analyses, a robust relationship was evident regardless of whether a child's mother, father, or sibling experienced pain. In case both parents reported pain compared with one, higher odds were evident.