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Familial aggregation and coaggregation of suicide attempts and comorbid mental disorders

JAMA Aug 14, 2019

Ballard ED, Cui L, Vandeleur C, et al. - In this study of data of 1,119 adult probands (mean age of 50 [12.0] years) and 5,355 first-degree relatives (mean age of 52 [1.5] years), researchers examined the familial patterns of suicide attempts and comorbid mental disorders and their connections in a 2-site family study of mood and anxiety disorders. From October 2004 to December 2016, data were gathered and analyzed. According to results, suicide attempts were moderately familial and linked to mental disorders, especially mood disorders. Suicide attempts in relatives was statistically significantly linked to social anxiety disorder in probands. Findings suggested that while suicide attempts seem familial, much of the familial aggregation may be due to mental comorbidity. The higher risk of suicide attempts among individuals with familial diathesis for social anxiety or its underlying components may provide insight into mechanisms and suicide prevention.

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