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Factors of microinflammation in non-diabetic chronic kidney disease: A pilot study

BMC Nephrology Apr 26, 2020

Olivier V, Dunyach-Remy C, Corbeau P, et al. - Researchers examined chronic kidney disease (CKD) patients without metabolic nor inflammatory disease, to determine the links between digestive bacterial translocation, uremic toxins, oxidative stress and microinflammation in this patient population. This study involved 44 patients with CKD from stage IIIB to V as well as 14 controls from the nephrology outpatients, who had normal kidney function. Besides, 11 patients under hemodialysis (HD) were also examined. According to the findings, a correlation of only p-cresyl sulfate, indoxyl sulfate, and urea with microinflammation was evident among CKD patients without any related metabolic nor inflammatory disease. Among patients under HD, reduced bacterial translocation was identified, and there was no correlation between bacterial translocation and microinflammation.

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