Chung KS, et al. - Researchers conducted this 5-year retrospective study of 168 individuals (138 males and 30 females) with opioid dependence who attempted to switch from methadone to buprenorphine/naloxone at their methadone maintenance treatment (MMT) clinics in Taiwan in order to determine the predictors for failed switching from methadone to buprenorphine/naloxone among these patients. Switching from methadone to buprenorphine/naloxone failed in 70 of the 168 participants (41.7%). Failed switching was observed in significant correlation to a greater average dose of methadone, a greater maximal maintenance dose of MMT, greater average dose of buprenorphine, and lower average attendance rate during the three months before switching following forward selection in the Cox hazard regression model. As per findings, they recommend clinicians to discuss with their patients regarding tapering the dose of methadone and improving their attendance if they want to switch from methadone to buprenorphine.