Mucci A, Galderisi S, Gibertoni D, et al. - Researchers performed this 4-year multicenter prospective cohort study among 618 clinically stable participants with schizophrenia to determine if baseline illness-associated variables, personal resources, and context-related factors were related to work skills, interpersonal relationships, as well as everyday life skills at 4-year follow-up in these patients. The main baseline factors that were identified to be related to real-life functioning at follow-up included social and nonsocial cognition, avolition, and positive symptoms. A link was evident between baseline everyday life skills and changes in work skills at follow-up. The observations indicated that functional outcome at follow-up was related to baseline variables including domains not routinely evaluated and targeted by intervention programs in community mental health services. The adoption of cognitive training programs, integrated with personalized psychosocial interventions aimed to encourage independent living, in routine mental health care is supported by the key roles of social and nonsocial cognition and of baseline everyday life skills.