Power JD, Perruccio AV, Gandhi R, et al. - Individuals with presurgical, end-stage osteoarthritis (OA) of the knee (n = 77), hip (n = 459), and spine (n = 168) were enrolled in this study in order to assess rates of prescription opioid use in this patient population and correlations between use and sociodemographic and health status features. Among individuals with spine OA, the use of opioids was greatest and comparable among individuals with knee and hip OA. Especially among individuals with spine OA, younger women (ages < 65 years) reported the greatest use of opioids overall. A greater possibility of opioid use was significantly correlated with spine OA (vs knee OA), obesity, being a current or past smoker, greater symptomatic joint count, bigger depressive symptoms, greater pain, and prevailing use of other prescription pain medication. In all, prescription opioid medication was utilized by approximately one-third of individuals with presurgical OA. Greater opioid use among younger individuals and those with depressive symptoms was the matter of concern and required additional investigation, provided the questionable efficiency of opioids in OA and the risk of adverse results.