Pani E, Kennedy G, Zhen X, et al. - Via a retrospective study (the largest dataset published to study patients with non-small cell lung cancer [NSCLC] ≤ 2 cm) of patients (n = 555) treated for NSCLC ≤ 2.0 cm at a single institution from 2005 to 2017, researchers recognized whether these patients may be safely spared the morbidity of lymphadenectomy. Primary independent variables comprised tumor size, histology, and histologic subtype. However tumors < 1 cm were less prone to have lymph node (LN) metastases than 1.1-2 cm tumors, there was no statistically meaningful variation. Histologic subtype was related to LN status. Micropapillary predominant tumors were more inclined to have LN metastases in an adenocarcinoma sub-group analysis. Every invasive mucinous adenocarcinoma and minimally invasive adenocarcinoma was N0. In conclusion, in patients with minimally invasive adenocarcinoma or invasive mucinous adenocarcinomas ≤ 2.0 cm, an LN assessment maybe not required. Nonetheless, this information is seldom available pre- or intraoperatively. Therefore, it was suggested that LN assessment always be done when possible, even for subcentimeter NSCLC, except when the histology is thoroughly accurate.