Armer JM, Ballman KV, McCall L, et al. - Through a cohort study of 486 patients with cT0-T4N1-2M0 breast cancer with documented axillary nodal metastasis at diagnosis, researchers investigated factors related to lymphedema following neoadjuvant chemotherapy (NAC) and axillary lymph node dissection in women with node-positive breast cancer. Rising BMI and NAC for 144 days or longer were correlated with lymphedema symptoms. Among individuals who got NAC for 144 days or longer, the V20 incidence was higher. In patients with 30 nodes or more removed, the V10 incidence was highest and it rose with the number of positive nodes. On multivariable analysis, obesity was significantly correlated with lymphedema symptoms and NAC length was significantly related to V20. In conclusion, longer NAC duration and obesity were correlated with progressed lymphedema incidence, proposing that patients in these groups may profit from improved prospective lymphedema surveillance.