Armer JM, et al. - Via a cohort study of 486 subjects with breast cancer, experts investigated factors correlated with lymphedema following neoadjuvant chemotherapy (NAC) and axillary lymph node dissection in women with node-positive breast cancer. Rising body mass index and NAC for 144 days or longer correlated with lymphedema symptoms. In cases that received NAC for 144 days or longer, incidence of an arm volume increase of 20% or more was higher. In those with 30 nodes or more removed, incidence of an arm volume increase of 10% or more was higher and increased with the number of positive nodes. Obesity was significantly correlated with lymphedema symptoms, and NAC length was significantly related an arm volume increase of 20% or more. Longer time on NAC and obesity were linked to heightened lymphedema incidence, which implied that patients in these groups should receive enhanced prospective lymphedema surveillance.