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Factors associated with kyphosis and kyphosis progression in older men: The MrOS study

Journal of Bone and Mineral Research Aug 20, 2020

Woods GN, Huang MH, Lee JH, et al. - Researchers investigated risk factors for hyperkyphosis (HK) [increased anterior curvature of the thoracic spine, defined as ≥ 50 degrees] and kyphosis progression among 1,092 men from the Osteoporotic Fractures in Men (MrOS) Study aged 64 to 92 years (mean age 72.8 years) who had repeated standardized radiographic measures of Cobb angle of kyphosis over an interval of 4.7 years. Men exhibited an average baseline kyphosis of 38.9 (standard deviation [SD] 11.4) degrees. HK was reported in 15% (n = 161) with a mean Cobb angle of 56.7 (SD = 6.0) degrees. Men with HK were older, had lower BMI, lower BMD, were more likely to have family history of HK, and prevalent thoracic vertebral fracture compared with the men without HK. During follow‐up, men had an average of 1.4 degrees of kyphosis progression; degenerative disc disease (DDD) and lower hip BMD were identified as statistically significant and incident vertebral fractures nearly significant factors associated with worse progression. These findings indicate that in older males, HK results from not only low BMD and vertebral fractures but that DDD also may play a significant role in kyphosis progression. 

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