Sun L, et al. - Patients with extended duration of prone positioning are at risk of developing orbital compartment syndrome if direct pressure to the orbit and the globe occurs and concomitant protection of the eyes is not undertaken. Researchers here reported ophthalmic abnormalities present in patients with coronavirus disease 2019 (COVID-19) in the intensive care unit requiring prolonged prone-position ventilation. From April 27, 2020, to May 4, 2020, four of 16 patients in the intensive care unit needed prolonged prone-position ventilation at a COVID-19 intensive care unit of a tertiary care hospital. Four selected patients received a bedside eye examination due to the presence of substantial periorbital edema. In this case series, 2 patients exhibited bilateral findings of optic disc edema and retinal hemorrhages as well as a substantial increase in intraocular pressure. Based on findings, they stress clinicians to be aware of the possible presence of raised intraocular pressure from periorbital edema due to direct eye and orbit compression, and optic disc edema and retinal hemorrhages, which may be linked with a hypercoagulable state, in patients with COVID-19 in prolonged prone position in the intensive care unit.