External evaluation of population pharmacokinetic models for cyclosporine in adult renal transplant recipients
British Journal of Clinical Pharmacology Sep 14, 2017
Mao JJ, et al. - In this study, the researchers examined the predictive ability of cyclosporine (CsA) population pharmacokinetic (popPK) models. The structural model was the predominant factor influencing model predictability. Implementation of nonlinear kinetics should be considered in CsA popPK modelling. In addition, Bayesian forecasting substantially improved model predictability.
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