Hurtado MD, et al. - In patients undergoing adrenalectomy for corticotropin-independent cortisol excess, the researchers identified predictors of hypothalamic-pituitary-adrenal (HPA) axis recovery interval and severity of glucocorticoid withdrawal symptoms (GWS). Between 1998 and 2017, the researchers performed a retrospective study of patients with mild autonomous cortisol excess (MACE), moderate and severe Cushing syndrome (CS) who developed adrenal insufficiency after unilateral adrenalectomy. For patients with severe CS, the HPA axis recovery interval was the longest. It was noted that patients with moderate CS recovered their HPA axis as quickly as those with MACE. GWS were noted in all groups, with more events in subjects with severe CS. Based on individual preoperative parameters, this research highlighted the need to counsel patients on expectations for HPA axis recovery and address intervention for GWS.