Kalim S, et al. - This inquiry was set up to determine the magnitude of change in metabolite profiles for patients on extended duration nocturnal hemodialysis. Researchers noted that extended duration hemodialysis was associated with modest changes in the plasma metabolome across a wide array of metabolites examined. Also, they noted that despite increased dialysis time, most differences were related to metabolite increases. With more dialysis, few metabolites showed reduction. Additionally, no change was apparent in several established uremic toxins.