Savonius O, et al. - Given their previous work in Luanda, Angola, demonstrating promising results with initial continuous β-lactam infusion for 24 hours combined with oral acetaminophen for 48 hours as a new treatment for childhood bacterial meningitis, researchers here examined if the outcomes further improve with extending this treatment regimen to 4 days. In this randomized, double-blind, parallel-group study, children aged 2 months to 15 years with symptoms and signs of bacterial meningitis were administered, for the first 4 days, a continuous infusion of cefotaxime (250 mg/kg/day) with simultaneous oral acetaminophen (first dose 30 mg/kg, then 20 mg/kg every 6 hours), or cefotaxime conventionally as boluses (62.5 mg/kg, 4 times per day) with placebo orally. From January 22, 2012 to January 21, 2017, 375 patients were assessed in this study. Outcomes revealed no improvement in the gloomy outcomes of childhood bacterial meningitis in correlation with using prolonged continuous β-lactam infusion combined with oral acetaminophen.