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Expression of ALCAM (CD166) and PD-L1 (CD274) independently predicts shorter survival in malignant pleural mesothelioma

Human Pathology Aug 17, 2017

Inaguma S, et al. – This study gauged the expressions of PD–L1 and stem cell marker in malignant mesotheliomas. The data displayed that thirty–three percent of the analyzed tumors (57/175) contained PD–L1–positive cells. Overall survival notably decreased in these patients with ALCAM– or PD–L1–positive tumors (both P < .01). The multivariate Cox hazards regression analysis determined ALCAM and PD–L1 (both P < 0.01) as potential independent risk factors. A combination of these two markers could be beneficial for the prognostication and planning of the treatment of patients with malignant pleural mesothelioma.
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