Matthews NH, et al. - Experts conducted a systematic review of published epidemiologic literature to examine the correlation between exposure to trace elements, and risk of melanoma and keratinocyte carcinoma in humans. They identified epidemiologic studies investigating exposure to arsenic, cadmium, chromium, copper, iron, selenium, and zinc and risk of skin cancer in humans. Results demonstrated an association of exposure to selenium with possible increased risk of keratinocyte carcinoma. Findings suggested the studies of zinc and skin cancer to be case–control in design and these studies were found to have inconsistent associations. In order to draw any conclusions, the data on the correlation between cadmium, chromium, copper, and iron and risk of skin cancer remain too sparse. They noted limited epidemiologic studies on exposure to trace elements and cutaneous malignancies.