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Expiratory variability index (EVI) is associated with the severity of acute bronchial obstruction in small children: A proof of concept study

Pediatric Allergy and Immunology Apr 25, 2020

Seppä VP, Turkalj M, Hult A, et al. - Through this analysis, the researchers sought to investigate how and the extent of an acute bronchial obstruction (BO) and its recovery reflects in expiratory variability index (EVI). In 40 healthy controls (aged 1.5-5.9 y) and 30 patients hospitalised due to acute BO (aged 1.3-5.3 y), EVI was assessed using a wearable impedance pneumography system (Ventica®) during sleep. In healthy controls, EVI was measured for 1-3 nights at home. During hospitalization, patients were measured as practically feasible for several nights and 2 and 4 weeks post-discharge at home. Seventy-nine EVI results were received from 39 controls and 139 from 30 patients. EVI was not significantly different from the controls at 2 or 4 weeks post-discharge. In wheezy children aged 1-5 years, EVI was found to be a sensitive, objective marker of acute BO, showing clear association with changes in clinical status.

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