• Profile
Close

Exercise preserves physical function in prostate cancer patients with bone metastases

Medicine and Science in Sports and Exercise Oct 28, 2017

Galvao DA, et al. - This study was initiated in order to gauge the efficacy and safety of a modular multi-modal exercise program in prostate cancer patients with bone metastases. The data unveiled that such an exercise program gave rise to self-reported improvements in physical function and objectively measured lower body muscle strength. It did not display skeletal complications or increased bone pain

Methods

  • The enrollment consisted of 57 prostate cancer patients (70.0+/-8.4 years; BMI 28.7+/-4.0 kg/m2) with bone metastases (pelvis 75.4%, femur 40.4%, rib/thoracic spine 66.7%, lumbar spine 43.9%, humerus 24.6%, other sites 70.2%), carried out between 2012 and 2015.
  • The candidates were allocated to multi-modal supervised aerobic, resistance and flexibility exercises undertaken thrice weekly (EX, n=28) or usual care (CON, n=29) for 3 months.
  • Physical function subscale of the SF-36 served as the primary endpoint, reflecting as an indicator of patient-rated physical functioning.
  • Objective measures of physical function, lower body muscle strength, body composition and fatigue were included as the secondary endpoints.
  • Safety evaluation was carried out by recording the incidence and severity of any adverse events, skeletal complications, and bone pain throughout the intervention.

Results

  • A prominent variation was noted among the groups for self-reported physical functioning (3.2 points, 95% CI 0.4-6.0 points; p=0.028) and lower body muscle strength (6.6 kg, 95% CI 0.6-12.7; p =0.033) at 3 months favouring EX.
  • No change, however, was reported between groups for lean mass (p=0.584), fat mass (p=0.598), or fatigue (p=0.964).
  • The occurrences of exercise-related adverse events or skeletal fractures were absent.
  • Differences were not found with regard to the bone pain, between EX and CON (p=0.507).

Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
  • Exclusive Write-ups & Webinars by KOLs

  • Nonloggedininfinity icon
    Daily Quiz by specialty
  • Nonloggedinlock icon
    Paid Market Research Surveys
  • Case discussions, News & Journals' summaries
Sign-up / Log In
x
M3 app logo
Choose easy access to M3 India from your mobile!


M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen
Okay