Brabin B, et al. -From a safety trial in an area of high malaria endemicity in Burkina Faso, researchers reported pre-specified secondary birth outcomes. Impacts of long-term weekly iron supplementation on malaria and genital tract infections in non-pregnant and pregnant women were assessed as the primary outcomes in that trial. Periconceptionally, 1,959 nulliparous, mainly adolescent women were provided either 60 mg elemental iron and 2.8 mg folic acid or 2.8 mg folic acid alone, weekly, continuing up to the first antenatal visit for those who became pregnant. Among these, 478 pregnancies resulted among 258/980 women assigned iron and folic acid and 220/979 women assigned folic acid alone. At the first antenatal visit, malaria prevalence was 53% in females who received iron and 55% in those who did not. Outcomes revealed a higher risk of preterm birth in the first pregnancy of nulliparous women in a malaria endemic area in correlation to long-term weekly iron supplementation given to them.