Yu S, Eftekhary N, Wiznia D, et al. - In view of the observation that patient outcomes and recovery could be improved among patients undergoing total knee arthroplasty (TKA) via perioperative pain management, researchers assessed the efficacy of preoperative oral acetaminophen vs intravenous (IV) acetaminophen administered once intraoperatively and once postoperatively in patients undergoing primary, unilateral TKA. Doses of oral acetaminophen were provided to the oral acetaminophen cohort (OA) preoperatively and on as-needed basis postoperatively (n = 698). In the IV acetaminophen cohort (IA), 2 doses of IV acetaminophen were administered, one intraoperative and one 6 hours postoperatively, with no oral acetaminophen given (n = 318). The IV acetaminophen group demonstrated less narcotic usage on postoperative day 0 and overall usage and showed statistically and significantly decreased pain scores in the immediate postoperative (the first 8 hours) period. They incorporated IV acetaminophen as an integral and effective part of their opioid-sparing multimodal pain regimen in TKA.