Law PCF, et al. – The reason for this examination was to investigate the association between eye movement (EM) profiles and binocular rivalry (BR) rate for various stimulus types in bipolar disorder (BD) and healthy subjects. The outcomes suggested that EM profiles do not explain the slow BR endophenotype for BD, thus showing that the trait reflects anomalous perceptual processing per se. This perceptual trait can be used in clinical, genetic, mechanistic and pathophysiological studies.

Methods

• Utilizing a repeated-measures within-subjects design, twenty BD outpatients and twenty age- and sex-matched healthy controls finished EM tasks and separate BR tasks including a range of stimuli with different drift speeds.
• After that, the relationship between each EM measure and BR rate was inspected with correlational analyses for all stimulus conditions in both groups.
• Between-group comparisons were performed to determine any differences in those EM measures.
• Finally, corresponding Bayesian analyses were also conducted.

Results

• It was observed in the findings that there were no EM measures that demonstrated a significant association with BR rate in either the BD group or the healthy group (P≥ 7.87×10^-3), where those EM measures were also significantly different between the BD and healthy groups (P≥1.32 × 10^-2).
• These discoveries were confirmed with Bayes factors.