Wagner M, et al. - Researchers assessed the trajectories of established cardiometabolic risk factors in the 14 years preceding incidence of dementia in this nested case-control study involving 3,925 participants (aged ≥ 65 years). They evaluated 785 cases of incident dementia and 3,140 control participants matched by sex, age, educational level, and cohort center at the time of diagnosis. They found that body mass index and blood pressure level trajectories of future dementia cases differed from control participants without dementia, resulting in lower levels at the approach of diagnosis, whereas trajectories of blood lipid levels remained similar between incident dementia cases and control participants. They also found that elevated glycemia concentration was the sole metabolic risk factor with constantly higher values among dementia cases up to 14 years prior to diagnosis. These findings suggested that lower blood pressure levels prior to dementia diagnosis might reflect both a consequence and a contributing factor for the disease. Higher blood glucose levels, however, may constitute a risk factor for dementia in the older age range. The authors suggested that, for primary and secondary prevention of dementia in the older age range, elevated glycemia, low blood pressure levels, and weight loss should be considered primary targets for the management of cardiometabolic health.