Sinnecker T, Clarke MA, Meier D, et al. - In this multicenter cross-sectional study, researchers focused on the utility of central vein sign on clinical 3T magnetic resonance imaging as a biomarker for the diagnosis of multiple sclerosis. From ongoing observational studies and neuroimaging research databases of eight neuroimaging centers in Europe, 648 participants were enrolled; after excluding 42 participants, 606 participants remained. According to the findings, the differentiation of multiple sclerosis from non–multiple sclerosis was possible with the use of a 35% central vein sign proportion threshold, with a sensitivity and specificity of 68.1% and 82.9%, respectively. Sensitivity and specificity of 61.9% and 89.0%, respectively, were yielded by the criteria of three or more central vein sign lesions. Overall, the high specificity of the 3T central vein sign–based criteria was evident for distinguishing multiple sclerosis from non–multiple sclerosis.