Torky HA, et al. - Nidogen-2 is a new tumour marker that when combined with higher sensitivity, specificity and accuracy than carbohydrate antigen (CA-125) and Doppler ultrasound improves the early diagnosis of ovarian cancer. In this study, Nidogen-2 was shown to be a new promising ovarian malignancy biomarker. It correlated closely with ultrasound and CA125, and also improved the accuracy of diagnosis.