Oppelaar MC, et al. -Investigators conducted a study comprising post-surgical (ENT, oral and maxillofacial) comparison of short-course (≤24 hours) and extended-course (≥72 hours) antibiotic prophylaxis. A sum of 1974 patients along with a meta-analysis of 21 articles was included in the research. No noticeable difference was established in the occurrence of postoperative infections in the patients who received short or long antibiotic prophylaxis. The recommendation of short-term antibiotic prophylaxis should be done unless the patient's condition demands an extended course, as there was no significant difference in the short-term or long-term antibiotic prophylaxis, postoperatively. Comorbidities, higher hospital costs, and antibiotic resistance development can be avoided by using short-term antibiotics. Future studies should evaluate the identification of risk groups that might take advantage of long-term antibiotic prophylaxis.