Sobas EM, Vázquez A, Videla S, et al. - In this multicenter, prospective, and descriptive study, researchers assessed the evolution of a set of proposed pain biomarkers in the saliva of individuals following Advanced Surface Ablation (ASA), in order to determine their validity as objective pain measures. This investigation was conducted to evaluate the variations between biomarkers and perceived pain. Participants in the study were healthy individuals who had a bilateral, alcohol-assisted surface ablation with epithelial removal (ASA). The two possible biomarkers presenting association with the Visual Analog Scale are sIgA and sTNFαRII in this study, and these salivary substances showed acceptable levels of reproducibility in healthy individuals.