Yang X, et al. - Using data from an independent prospective population-based cohort study, the researchers assessed the combined effects of epithelial ovarian cancer (EOC) susceptibility single nucleotide polymorphisms (SNPs) on predicting EOC risk. From the UK Collaborative Trial of Ovarian Cancer Screening trial, they genotyped ovarian cancer susceptibility SNPs in a nested case–control study (750 cases and 1428 controls). They suggested that PRSs could be used to foresee the future risk of developing ovarian cancer for women in the general population. However, incorporation of polygenic risk scores (PRSs) into risk prediction models for EOC could inform clinical decision-making and health management.