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Evaluation of photoreceptor function in inherited retinal diseases using rod‐ and cone‐enhanced flicker stimuli

Ophthalmic and Physiological Optics Apr 14, 2021

Hathibelagal AR, Bharadwaj SR, Jalali S, et al. - Experts aspired to explore whether rod/cone sensitivity losses could be measured accurately in patients with retinal diseases that selectively affect rods or cones when compared to age‐matched subjects with normal vision. Flicker modulation thresholds (FMTs) have been measured psychophysically, utilizing cone‐ and rod‐enhanced stimuli located centrally, and in four quadrants, at 5° retinal eccentricity in 20 patients (age range: 10–41 years) with cone‐dominated (Stargardt's disease or macular dystrophy; n = 13) and rod‐dominated (retinitis pigmentosa; n = 7) disease. In cone-dominated diseases, cone-specific deficits were greater than rod-specific deficits, and vice versa in rod-dominated diseases. Such findings indicate that the new method of determining photoreceptor sensitivity could be used to detect specific rod/cone losses without requiring dark adaptation.

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