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Evaluation of maternal serum biomarkers in predicting outcome of successful expectant management of tubal ectopic pregnancies

European Journal of Obstetrics & Gynecology and Reproductive Biology May 04, 2020

Memtsa M, Jauniaux E, Gulbis B, et al. - Researchers examined the predictive value of multiple serum biomarkers for successful outcome of expectant management in women with tubal ectopic pregnancy (TEP). They performed a blood test to measure β-human chorionic gonadotropin (β-hCG), progesterone, inhibin A, activin A and high sensitivity C-reactive protein (hsCRP) at the initial visit among women with a conclusive ultrasound diagnosis of TEP. The final cohort comprised 93 women with a TEP. Among these, emergency surgery was performed on 42 (45%) women whilst 51 (55%) were managed expectantly. Per multi-variable analysis, there was a lower chance of successful expectant management of TEP only in correlation with higher values of serum β-hCG and progesterone at the initial visit. A one-unit raise in either variable on the log-scale was linked with an about 20-fold decrease in the odds of a successful outcome.

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