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Evaluation of a city-wide school-located influenza vaccination program in Oakland, California, with respect to vaccination coverage, school absences, and laboratory-confirmed influenza: A matched cohort study

PLoS Medicine Aug 25, 2020

Benjamin-Chung J, Arnold BF, Kennedy CJ, et al. - A city-wide school-located influenza vaccination (SLIV) intervention that aimed to enhance influenza vaccination coverage was evaluated in this study. Implementation of the intervention was done in ≥ 95 preschools and elementary schools in northern California from 2014 to 2018. Researchers here used a matched cohort design to ascertain the impacts of the intervention on student influenza vaccination coverage, school absenteeism, and community-wide indirect effects on laboratory-confirmed influenza hospitalizations. A nearby comparison school district with preintervention characteristics similar to those of the intervention school district and matched schools in each district were identified using a multivariate matching algorithm. Student influenza vaccination was measured conducting cross-sectional surveys of student caregivers in 22 school pairs (2017 survey, N = 6,070; 2018 survey, N = 6,507). Surveillance data from school district zip codes were used to determine the incidence of laboratory-confirmed influenza hospitalization from 2011 to 2018. Per analysis, by the third and fourth years of the program, students in the SLIV site had 7%–11% higher influenza vaccination coverage relative to the comparison site. In those years, significantly lower influenza hospitalization rates among non-elementary-school-aged individuals and among the elderly were reported in correlation with the SLIV program. Moreover, fewer absences due to illness were reported in the SLIV site vs the comparison site in those years. These findings suggest that the intervention may have produced herd effects.

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