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Etomidate use is associated with less hypotension than ketamine for emergency department sepsis intubations: A near cohort study

Academic Emergency Medicine Jul 27, 2020

Mohr NM, Pape SG, Runde D, et al. - In this observational cohort study of the prospective National Emergency Airway Registry (NEAR) data set, researchers investigated the current use of etomidate and other induction agents in patients with sepsis. Further, they compared adverse events between etomidate and ketamine in sepsis. Intubation of a total of 531 patients was reported for sepsis, and the majority (71%) were intubated with etomidate as the initial induction agent. Relative to nonsepsis patients, sepsis patients less frequently had etomidate use, with ketamine being the most frequently used alternative. More postprocedural hypotension was observed in correlation with ketamine vs etomidate.

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